EAN: 9781441999139

Bilder-Quelle: shopping24.de – Beauty

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens thus playing critical roles in preventing autoimmune diseases they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

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03.04.2025 um 12:18 Uhr

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