EAN: 9783030147914

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This book reviews the chemical regulatory and physiological mechanisms of protein arginine and lysine methyltransferases as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases which target other amino acids in peptidyl side chains or N-termini and C-termini such as glutamate glutamine and histidine. All these protein methyltransferases use a similar mechanism. In contrast nucleic acids (DNA and RNA) are substrates for methylating enzymes which employ various chemical mechanisms to methylate nucleosidesat nitrogen (N) oxygen (O) and carbon (C) atoms. This book illustrates how thanks to there ability to expand their repertoire of functions to the modified substrates protein and nucleic acid methylation processes play a key role in cells.

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06.05.2025 um 15:42 Uhr

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