EAN: 9783319396620

Bilder-Quelle: discount24.de - Sport-Freizeit

This volume focuses on various aspects of interleukin-27 (IL-27) especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1 Th2 Th17 Treg Tr1 Tfh B cells DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus multiple sclerosis autoimmune uveitis immune thrombocytopenia and atherosclerosis. However the same inhibitory capabilities compromise the immune response to bacterial pathogens and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis the effect of IL-27 on epithelia which seems to play a role in asthma psoriasis and inflammatory bowel diseases and the direct cytotoxic and anti-vascular effects of IL-27 which make it a promising agent for the treatment of cancer. Accordingly this volume will be of interest to researchers and clinicians alike.

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31.03.2025 um 06:46 Uhr

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