EAN: 9783662110409

Bilder-Quelle: discount24.de - Sport-Freizeit

Stress-induced myocardial ischemia is a frequent manifestation of coronary heart disease and sympathetic activation is an important precipitating and aggravating factor in such stress induced ischemia. However the complex interplay between the sympathetic initiation of myocardial ischemia ischemia-induced alterations in sympathetic neurotransmission as well as changes in adrenoceptor density and post-receptor signal transduction that can occur during ischemia remains incompletely understood. Not only the activation of myocardial fJ adrenoceptors but also the activation of coronary IX-adrenoceptors can contribute to myocar dial ischemia. However the role of fJ-adrenoceptor-mediated increases in contractility relative to heart rate in the initiation of ischemia is not clear and the significance of IX-adrenoceptor mediated changes in coronary vasomotor tone as well as the responsible IX-adrenoceptor subtypes are highly controversial. Malignant arrhythmias may be triggered by both IX- and fJ-adrenergic mechanisms. Current research in this field is focussed not only on the underlying physiological and pathophysiological mechanisms but also on clinical treatment strategies e. g. by fJ-blockade IX-blockade bradycardic agents and calcium antagonists. Recent findings were presented and future research directions discussed during the 61 International Titisee Conference held at the Schwarzwald-Hotel Titisee March 29-31 1990 under the sponsorship of the Boehringer Ingelheim Foundation. Dr. Hasso Schroeder and Dr. Hermann Frohlich deserve special thanks for their generous support and pleasant organization of the meeting. The publication of the proceedings has been made possible by grants from Astra Chemicals Bayer ICI Dr. Karl Thomae and Upjohn.

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04.11.2025 um 01:19 Uhr

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