9781475745214 - Cancer Drug Discovery and Development Antifolate Drugs in Cancer Therapy Kartoniert (TB)

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In Antifolate Drugs in Cancer Therapy Ann Jackman and a panel of highly regarded researchers comprehensively review the current status of novel antifolates an important class of anticancer drugs. The distinguished contributors discuss the preclinical and clinical pharmacology of methotrexate other dihydrofolate reductase inhibitors 5-fluorouracil and the new generation of antifolates-the thymidylate synthase and glycinamide ribonucleotide formyltransferase inhibitors. In addition they review in depth the modulation of antifolate drugs folate and antifolate transport mechanisms polyglutamation resistance and drug combinations as well as pharmacogenomics pharmacodynamics regulation of gene expression and mechanisms of cell death. The wide and progressive scope of Antifolate Drugs in Cancer Therapy provides entré to exciting new avenues for future research and constitutes a new standard reference for all basic scientists and clinicians engaged in cancer therapeutics.

Produktinformationen zuletzt aktualisiert am
25.03.2025 um 18:03 Uhr

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9781475745214

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