EAN: 9781627037419

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Thoroughly revised and updated Optimization in Drug Discovery: In Vitro Methods Second Edition presents a wide spectrum of in vitro assays including formulation plasma binding absorption and permeability cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism CYP inhibition and induction drug transporters drug-drug interactions via assessment of reactive metabolites genotoxicity and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible protocols and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve drug-like characteristics in addition to efficacy properties and good safety profiles of drug candidates.Comprehensive and up-to-date Optimization in Drug Discovery: In Vitro Methods Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

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05.04.2025 um 01:20 Uhr

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