EAN: 9783642543784

Bilder-Quelle: shopping24.de – Beauty

Filaggrin gene mutations are common in Europeans and their descendants as well as in Asians reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration keep the skin pH low and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover they have 10% higher serum vitamin D levels potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science epidemiology management and future research areas.

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31.10.2025 um 15:27 Uhr

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